Early detection of the aflatoxin B(1) mutational fingerprint: A diagnostic tool for liver cancer

Using duplex-consensus sequencing technology, we recently identified the characteristic high-resolution mutational spectrum of the liver carcinogen aflatoxin B(1) in a mouse model, many months before aflatoxin-induced tumors are detectable. The diagnostic power of this spectrum is then demonstrated...

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Autores principales: Fedeles, Bogdan I., Chawanthayatham, Supawadee, Croy, Robert G., Wogan, Gerald N., Essigmann, John M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540215/
https://www.ncbi.nlm.nih.gov/pubmed/28868344
http://dx.doi.org/10.1080/23723556.2017.1329693
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author Fedeles, Bogdan I.
Chawanthayatham, Supawadee
Croy, Robert G.
Wogan, Gerald N.
Essigmann, John M.
author_facet Fedeles, Bogdan I.
Chawanthayatham, Supawadee
Croy, Robert G.
Wogan, Gerald N.
Essigmann, John M.
author_sort Fedeles, Bogdan I.
collection PubMed
description Using duplex-consensus sequencing technology, we recently identified the characteristic high-resolution mutational spectrum of the liver carcinogen aflatoxin B(1) in a mouse model, many months before aflatoxin-induced tumors are detectable. The diagnostic power of this spectrum is then demonstrated by accurately identifying, among the sequenced human liver tumors, the subset of cancers associated with aflatoxin B(1) exposure.
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spelling pubmed-55402152018-05-19 Early detection of the aflatoxin B(1) mutational fingerprint: A diagnostic tool for liver cancer Fedeles, Bogdan I. Chawanthayatham, Supawadee Croy, Robert G. Wogan, Gerald N. Essigmann, John M. Mol Cell Oncol Author's View Using duplex-consensus sequencing technology, we recently identified the characteristic high-resolution mutational spectrum of the liver carcinogen aflatoxin B(1) in a mouse model, many months before aflatoxin-induced tumors are detectable. The diagnostic power of this spectrum is then demonstrated by accurately identifying, among the sequenced human liver tumors, the subset of cancers associated with aflatoxin B(1) exposure. Taylor & Francis 2017-05-19 /pmc/articles/PMC5540215/ /pubmed/28868344 http://dx.doi.org/10.1080/23723556.2017.1329693 Text en © 2017 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author's View
Fedeles, Bogdan I.
Chawanthayatham, Supawadee
Croy, Robert G.
Wogan, Gerald N.
Essigmann, John M.
Early detection of the aflatoxin B(1) mutational fingerprint: A diagnostic tool for liver cancer
title Early detection of the aflatoxin B(1) mutational fingerprint: A diagnostic tool for liver cancer
title_full Early detection of the aflatoxin B(1) mutational fingerprint: A diagnostic tool for liver cancer
title_fullStr Early detection of the aflatoxin B(1) mutational fingerprint: A diagnostic tool for liver cancer
title_full_unstemmed Early detection of the aflatoxin B(1) mutational fingerprint: A diagnostic tool for liver cancer
title_short Early detection of the aflatoxin B(1) mutational fingerprint: A diagnostic tool for liver cancer
title_sort early detection of the aflatoxin b(1) mutational fingerprint: a diagnostic tool for liver cancer
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540215/
https://www.ncbi.nlm.nih.gov/pubmed/28868344
http://dx.doi.org/10.1080/23723556.2017.1329693
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