Cancer stem cell-related gene expression as a potential biomarker of response for first-in-class imipridone ONC201 in solid tumors

Cancer stem cells (CSCs) correlate with recurrence, metastasis and poor survival in clinical studies. Encouraging results from clinical trials of CSC inhibitors have further validated CSCs as therapeutic targets. ONC201 is a first-in-class small molecule imipridone in Phase I/II clinical trials for...

Descripción completa

Detalles Bibliográficos
Autores principales: Prabhu, Varun V., Lulla, Amriti R., Madhukar, Neel S., Ralff, Marie D., Zhao, Dan, Kline, Christina Leah B., Van den Heuvel, A. Pieter J., Lev, Avital, Garnett, Mathew J., McDermott, Ultan, Benes, Cyril H., Batchelor, Tracy T., Chi, Andrew S., Elemento, Olivier, Allen, Joshua E., El-Deiry, Wafik S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540272/
https://www.ncbi.nlm.nih.gov/pubmed/28767654
http://dx.doi.org/10.1371/journal.pone.0180541

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540272/
https://www.ncbi.nlm.nih.gov/pubmed/28767654
http://dx.doi.org/10.1371/journal.pone.0180541

Ejemplares similares