Engaging the CD40-CD40L pathway augments T-helper cell responses and improves control of Mycobacterium tuberculosis infection

Mycobacterium tuberculosis (Mtb) impairs dendritic cell (DC) functions and induces suboptimal antigen-specific CD4 T cell immune responses that are poorly protective. Mucosal T-helper cells producing IFN-γ (Th(1)) and IL-17 (Th(17)) are important for protecting against tuberculosis (TB), but the mec...

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Detalles Bibliográficos
Autores principales: Sia, Jonathan Kevin, Bizzell, Erica, Madan-Lala, Ranjna, Rengarajan, Jyothi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540402/
https://www.ncbi.nlm.nih.gov/pubmed/28767735
http://dx.doi.org/10.1371/journal.ppat.1006530

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540402/
https://www.ncbi.nlm.nih.gov/pubmed/28767735
http://dx.doi.org/10.1371/journal.ppat.1006530

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