Sec17/Sec18 act twice, enhancing membrane fusion and then disassembling cis-SNARE complexes

At physiological protein levels, the slow HOPS- and SNARE-dependent fusion which occurs upon complete SNARE zippering is stimulated by Sec17 and Sec18:ATP without requiring ATP hydrolysis. To stimulate, Sec17 needs its central residues which bind the 0-layer of the SNARE complex and its N-terminal a...

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Detalles Bibliográficos
Autores principales: Song, Hongki, Orr, Amy, Duan, Mengtong, Merz, Alexey J, Wickner, William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540461/
https://www.ncbi.nlm.nih.gov/pubmed/28718762
http://dx.doi.org/10.7554/eLife.26646

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540461/
https://www.ncbi.nlm.nih.gov/pubmed/28718762
http://dx.doi.org/10.7554/eLife.26646

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