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Pharmacoperone rescue of vasopressin 2 receptor mutants reveals unexpected constitutive activity and coupling bias

Pharmacoperones are small molecules that diffuse into cells and rescue misfolded, mistrafficked protein mutants, restoring their function. These substances act with high target specificity, serving as templates to fold (or refold) receptors, enzymes, ion channels or other proteins and enable them to...

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Detalles Bibliográficos
Autores principales: Janovick, Jo Ann, Spicer, Timothy P., Bannister, Thomas D., Scampavia, Louis, Conn, P. Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540481/
https://www.ncbi.nlm.nih.gov/pubmed/28767678
http://dx.doi.org/10.1371/journal.pone.0181830