Antibody-induced dimerization of FGFR1 promotes receptor endocytosis independently of its kinase activity

Fibroblast growth factors (FGFs) and their plasma membrane-localized receptors (FGFRs) play a key role in the regulation of developmental processes and metabolism. Aberrant FGFR signaling is associated with the progression of serious metabolic diseases and human cancer. Binding of FGFs to FGFRs indu...

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Detalles Bibliográficos
Autores principales: Opaliński, Łukasz, Sokołowska-Wędzina, Aleksandra, Szczepara, Martyna, Zakrzewska, Małgorzata, Otlewski, Jacek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540934/
https://www.ncbi.nlm.nih.gov/pubmed/28769084
http://dx.doi.org/10.1038/s41598-017-07479-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540934/
https://www.ncbi.nlm.nih.gov/pubmed/28769084
http://dx.doi.org/10.1038/s41598-017-07479-z

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