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Antibody-induced dimerization of FGFR1 promotes receptor endocytosis independently of its kinase activity
Fibroblast growth factors (FGFs) and their plasma membrane-localized receptors (FGFRs) play a key role in the regulation of developmental processes and metabolism. Aberrant FGFR signaling is associated with the progression of serious metabolic diseases and human cancer. Binding of FGFs to FGFRs indu...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540934/ https://www.ncbi.nlm.nih.gov/pubmed/28769084 http://dx.doi.org/10.1038/s41598-017-07479-z |