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Mammalian cells lack checkpoints for tetraploidy, aberrant centrosome number, and cytokinesis failure
BACKGROUND: Mammalian cells have been reported to have a p53-dependent tetraploidy checkpoint that blocks cell cycle progression in G1 in response to failure of cell division. In most cases where the tetraploidy checkpoint has been observed cell division was perturbed by anti-cytoskeleton drug treat...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
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BioMed Central
2005
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC554097/ https://www.ncbi.nlm.nih.gov/pubmed/15713235 http://dx.doi.org/10.1186/1471-2121-6-6 |