Cargando…

The Role of Replication-Associated Repair Factors on R-Loops

The nascent RNA can reinvade the DNA double helix to form a structure termed the R-loop, where a single-stranded DNA (ssDNA) is accompanied by a DNA-RNA hybrid. Unresolved R-loops can impede transcription and replication processes and lead to genomic instability by a mechanism still not fully unders...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bhatia, Vaibhav, Herrera-Moyano, Emilia, Aguilera, Andrés, Gómez-González, Belén
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541304/ https://www.ncbi.nlm.nih.gov/pubmed/28653981 http://dx.doi.org/10.3390/genes8070171

Ejemplares similares

The yeast and human FACT chromatin-reorganizing complexes solve R-loop-mediated transcription–replication conflicts
por: Herrera-Moyano, Emilia, et al.
Publicado: (2014)

R-loops do not accumulate in transcription-defective hpr1-101 mutants: implications for the functional role of THO/TREX
por: Gómez-González, Belén, et al.
Publicado: (2009)

The Fanconi Anemia Pathway Protects Genome Integrity from R-loops
por: García-Rubio, María L., et al.
Publicado: (2015)

A role for the Saccharomyces cerevisiae Rtt109 histone acetyltransferase in R-loop homeostasis and associated genome instability
por: Cañas, Juan Carlos, et al.
Publicado: (2022)

The chromatin network helps prevent cancer-associated mutagenesis at transcription-replication conflicts
por: Bayona-Feliu, Aleix, et al.
Publicado: (2023)

A new role for Rrm3 in repair of replication-born DNA breakage by sister chromatid recombination
por: Muñoz-Galván, Sandra, et al.
Publicado: (2017)

Transcription-mediated replication hindrance: a major driver of genome instability
por: Gómez-González, Belén, et al.
Publicado: (2019)

Topoisomerase 1-dependent R-loop deficiency drives accelerated replication and genomic instability
por: Sarni, Dan, et al.
Publicado: (2022)

A unified model for the molecular basis of Xeroderma pigmentosum-Cockayne Syndrome
por: Moriel-Carretero, María, et al.
Publicado: (2015)

The Npl3 hnRNP prevents R-loop-mediated transcription–replication conflicts and genome instability
por: Santos-Pereira, José M., et al.
Publicado: (2013)

Rpd3L and Hda1 histone deacetylases facilitate repair of broken forks by promoting sister chromatid cohesion
por: Ortega, Pedro, et al.
Publicado: (2019)

The rem Mutations in the ATP-Binding Groove of the Rad3/XPD Helicase Lead to Xeroderma pigmentosum-Cockayne Syndrome-Like Phenotypes
por: Herrera-Moyano, Emilia, et al.
Publicado: (2014)

Replication Fork Protection Factors Controlling R-Loop Bypass and Suppression
por: Chang, Emily Yun-Chia, et al.
Publicado: (2017)

Different genetic requirements for repair of replication-born double-strand breaks by sister-chromatid recombination and break-induced replication
por: Cortés-Ledesma, Felipe, et al.
Publicado: (2007)

TDP-43 mutations link Amyotrophic Lateral Sclerosis with R-loop homeostasis and R loop-mediated DNA damage
por: Giannini, Marta, et al.
Publicado: (2020)

DNA-RNA hybrids at DSBs interfere with repair by homologous recombination
por: Ortega, Pedro, et al.
Publicado: (2021)

R-loops and initiation of DNA replication in human cells: a missing link?
por: Lombraña, Rodrigo, et al.
Publicado: (2015)

TRF1 averts chromatin remodelling, recombination and replication dependent-break induced replication at mouse telomeres
por: Porreca, Rosa Maria, et al.
Publicado: (2020)

ARID1A regulates R-loop associated DNA replication stress
por: Tsai, Shuhe, et al.
Publicado: (2021)

Replication protein A associates with nucleolar R loops and regulates rRNA transcription and nucleolar morphology
por: Feng, Shuang, et al.
Publicado: (2021)

Depletion of the MFAP1/SPP381 Splicing Factor Causes R-Loop-Independent Genome Instability
por: Salas-Armenteros, Irene, et al.
Publicado: (2019)

DNA in 3R: Repair, Replication, and Recombination
por: Coin, Frédéric, et al.
Publicado: (2012)

A picornaviral loop-to-loop replication complex
por: Claridge, Jolyon K., et al.
Publicado: (2009)

Editorial: The Role of RNA in Genome Stability: To Wreck or Repair?
por: Gómez-González, Belén, et al.
Publicado: (2022)

R-Loop Mediated Transcription-Associated Recombination in trf4Δ Mutants Reveals New Links between RNA Surveillance and Genome Integrity
por: Gavaldá, Sandra, et al.
Publicado: (2013)

Elongation Factor TFIIS Prevents Transcription Stress and R-Loop Accumulation to Maintain Genome Stability
por: Zatreanu, Diana, et al.
Publicado: (2019)

The Role of the Stem-Loop A RNA Promoter in Flavivirus Replication
por: Choi, Kyung H.
Publicado: (2021)

Role of Chromatin Replication in Transcriptional Plasticity, Cell Differentiation and Disease
por: López-Jiménez, Elena, et al.
Publicado: (2022)

High-Resolution Mapping of Homologous Recombination Events in rad3 Hyper-Recombination Mutants in Yeast
por: Andersen, Sabrina L., et al.
Publicado: (2016)

Harmful R-loops are prevented via different cell cycle-specific mechanisms
por: San Martin-Alonso, Marta, et al.
Publicado: (2021)

Replication forks, chromatin loops and dormant replication origins
por: Blow, J Julian, et al.
Publicado: (2008)

TDP-43 dysfunction results in R-loop accumulation and DNA replication defects
por: Wood, Matthew, et al.
Publicado: (2020)

The integrated stress response induces R-loops and hinders replication fork progression
por: Choo, Josephine Ann Mun Yee, et al.
Publicado: (2020)

Supercoiling, R-Loops, Replication and the Functions of Bacterial Type 1A Topoisomerases
por: Brochu, Julien, et al.
Publicado: (2020)

From R-Loops to G-Quadruplexes: Emerging New Threats for the Replication Fork
por: Maffia, Antonio, et al.
Publicado: (2020)

Npl3 stabilizes R‐loops at telomeres to prevent accelerated replicative senescence
por: Pérez‐Martínez, Lara, et al.
Publicado: (2020)

Human RTEL1 associates with Poldip3 to facilitate responses to replication stress and R-loop resolution
por: Björkman, Andrea, et al.
Publicado: (2020)

Competing roles of DNA end resection and non-homologous end joining functions in the repair of replication-born double-strand breaks by sister-chromatid recombination
por: Muñoz-Galván, Sandra, et al.
Publicado: (2013)

Genome-Wide Analysis of Factors Affecting Transcription Elongation and DNA Repair: A New Role for PAF and Ccr4-Not in Transcription-Coupled Repair
por: Gaillard, Hélène, et al.
Publicado: (2009)

Repeat RNAs associate with replication forks and post-replicative DNA
por: Gylling, Helene M., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_t48qut4pfcmtutuvm2onbraa0a