Pre-Replicative Repair of Oxidized Bases Maintains Fidelity in Mammalian Genomes: The Cowcatcher Role of NEIL1 DNA Glycosylase

Genomic fidelity in the humans is continuously challenged by genotoxic reactive oxygen species (ROS) generated both endogenously during metabolic processes, and by exogenous agents. Mispairing of most ROS-induced oxidized base lesions during DNA replication induces mutations. Although bulky base add...

Descripción completa

Detalles Bibliográficos
Autores principales: Rangaswamy, Suganya, Pandey, Arvind, Mitra, Sankar, Hegde, Muralidhar L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541308/
https://www.ncbi.nlm.nih.gov/pubmed/28665322
http://dx.doi.org/10.3390/genes8070175

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541308/
https://www.ncbi.nlm.nih.gov/pubmed/28665322
http://dx.doi.org/10.3390/genes8070175

Ejemplares similares