Progression of pathology in PINK1-deficient mouse brain from splicing via ubiquitination, ER stress, and mitophagy changes to neuroinflammation

BACKGROUND: PINK1 deficiency causes the autosomal recessive PARK6 variant of Parkinson’s disease. PINK1 activates ubiquitin by phosphorylation and cooperates with the downstream ubiquitin ligase PARKIN, to exert quality control and control autophagic degradation of mitochondria and of misfolded prot...

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Detalles Bibliográficos
Autores principales: Torres-Odio, Sylvia, Key, Jana, Hoepken, Hans-Hermann, Canet-Pons, Júlia, Valek, Lucie, Roller, Bastian, Walter, Michael, Morales-Gordo, Blas, Meierhofer, David, Harter, Patrick N., Mittelbronn, Michel, Tegeder, Irmgard, Gispert, Suzana, Auburger, Georg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541666/
https://www.ncbi.nlm.nih.gov/pubmed/28768533
http://dx.doi.org/10.1186/s12974-017-0928-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541666/
https://www.ncbi.nlm.nih.gov/pubmed/28768533
http://dx.doi.org/10.1186/s12974-017-0928-0

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