Spontaneous loss of B lineage transcription factors leads to pre-B leukemia in Ebf1(+/–)Bcl-x(L)(Tg) mice

Early B-cell factor 1 (EBF1) plays a central role in B-cell lineage specification and commitment. Loss of this critical transcription factor is strongly associated with high-risk, relapsed and therapy-resistant B–cell-acute lymphoblastic leukemia, especially in children. However, Ebf1 haploinsuffici...

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Detalles Bibliográficos
Autores principales: Ramírez-Komo, J A, Delaney, M A, Straign, D, Lukin, K, Tsang, M, Iritani, B M, Hagman, J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541707/
https://www.ncbi.nlm.nih.gov/pubmed/28692033
http://dx.doi.org/10.1038/oncsis.2017.55

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541707/
https://www.ncbi.nlm.nih.gov/pubmed/28692033
http://dx.doi.org/10.1038/oncsis.2017.55

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