Cargando…

Aspartate β-hydroxylase disrupts mitochondrial DNA stability and function in hepatocellular carcinoma

The mechanism of aberrant mitochondrial genome and function in hepatocellular carcinoma (HCC) remains largely unknown. Our previous study demonstrated an increased expression of aspartate β-hydroxylase (ASPH) in HCC tissues, which was associated with tumor invasiveness and a worse prognosis. Current...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tang, C, Hou, Y, Wang, H, Wang, K, Xiang, H, Wan, X, Xia, Y, Li, J, Wei, W, Xu, S, Lei, Z, Pawlik, T M, Wu, M, Shen, F
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541716/ https://www.ncbi.nlm.nih.gov/pubmed/28714949 http://dx.doi.org/10.1038/oncsis.2017.64

Ejemplares similares

Diverse molecular functions of aspartate β-hydroxylase in cancer
por: Zheng, Wenqian, et al.
Publicado: (2020)

Aspartate β-hydroxylase as a target for cancer therapy
por: Kanwal, Madiha, et al.
Publicado: (2020)

Construction and Characterization of Adenovirus Vectors Encoding Aspartate-β-Hydroxylase to Preliminary Application in Immunotherapy of Hepatocellular Carcinoma
por: Zhou, Yujiao, et al.
Publicado: (2018)

Hydroxylase Activity of ASPH Promotes Hepatocellular Carcinoma Metastasis Through Epithelial-to-Mesenchymal Transition Pathway
por: Zou, Qifei, et al.
Publicado: (2018)

Aspartate β-Hydroxylase Serves as a Prognostic Biomarker for Neoadjuvant Chemotherapy in Gastric Cancer
por: Gan, Xuejun, et al.
Publicado: (2023)

Aspartate β-hydroxylase expression promotes a malignant pancreatic cellular phenotype
por: Dong, Xiaoqun, et al.
Publicado: (2014)

Aspartate-β-hydroxylase (ASPH): A potential therapeutic target in human malignant gliomas
por: Sturla, Lisa-Marie, et al.
Publicado: (2016)

Correction: Aspartate β-hydroxylase expression promotes a malignant pancreatic cellular phenotype
por: Dong, Xiaoqun, et al.
Publicado: (2019)

Aspartate-β-Hydroxylase: A Promising Target to Limit the Local Invasiveness of Colorectal Cancer
por: Benelli, Roberto, et al.
Publicado: (2020)

Characterization of the Relationship Between the Expression of Aspartate β-Hydroxylase and the Pathological Characteristics of Breast Cancer
por: Zhang, Yanan, et al.
Publicado: (2020)

Aspartate β-hydroxylase promotes pancreatic ductal adenocarcinoma metastasis through activation of SRC signaling pathway
por: Ogawa, Kosuke, et al.
Publicado: (2019)

Synthesis of Novel Pyridine‐Carboxylates as Small‐Molecule Inhibitors of Human Aspartate/Asparagine‐β‐Hydroxylase
por: Brewitz, Lennart, et al.
Publicado: (2020)

Novel Approach to Overcome Defects of Cell-SELEX in Developing Aptamers against Aspartate β-Hydroxylase
por: Bakhtiari, Hadi, et al.
Publicado: (2021)

Synthesis of 2-oxoglutarate derivatives and their evaluation as cosubstrates and inhibitors of human aspartate/asparagine-β-hydroxylase
por: Brewitz, Lennart, et al.
Publicado: (2020)

Aspartate β-Hydroxylase (ASPH) Expression in Acute Myeloid Leukemia: A Potential Novel Therapeutic Target
por: Holtzman, Noa G., et al.
Publicado: (2021)

Endocrine sensitivity of estrogen receptor‐positive breast cancer is negatively correlated with aspartate‐β‐hydroxylase expression
por: Shimoda, Masafumi, et al.
Publicado: (2017)

Small-molecule active pharmaceutical ingredients of approved cancer therapeutics inhibit human aspartate/asparagine-β-hydroxylase
por: Brewitz, Lennart, et al.
Publicado: (2020)

Kinetic parameters of human aspartate/asparagine–β-hydroxylase suggest that it has a possible function in oxygen sensing
por: Brewitz, Lennart, et al.
Publicado: (2020)

Aspartate/asparagine-β-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors
por: Brewitz, Lennart, et al.
Publicado: (2020)

Aspartate beta-hydroxylase domain containing 1 as a prognostic marker associated with immune infiltration in skin cutaneous melanoma
por: Sun, Shiquan, et al.
Publicado: (2023)

Aspartate/asparagine-β-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern
por: Pfeffer, Inga, et al.
Publicado: (2019)

Author Correction: Aspartate/asparagine-β-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors
por: Brewitz, Lennart, et al.
Publicado: (2020)

Molecular cloning, expression analysis and functional characterization of chicken cytochrome P450 27A1: A novel mitochondrial vitamin D(3) 25-hydroxylase
por: Shang, S., et al.
Publicado: (2023)

Immunochemical characterization of brain and pineal tryptophan hydroxylase.
por: Chung, Y. I., et al.
Publicado: (2001)

Stabilization of tryptophan hydroxylase 2 by l‐phenylalanine‐induced dimerization
por: Tidemand, Kasper D., et al.
Publicado: (2016)

Arginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction
por: Cheng, Chun-Ting, et al.
Publicado: (2018)

Identification and characterization of a novel human hepatocellular carcinoma-associated gene
por: Wang, Z-X, et al.
Publicado: (2001)

Mitochondrial uncoupling and the disruption of the metabolic network in hepatocellular carcinoma
por: Turcios, Lilia, et al.
Publicado: (2020)

Genetic Disruption of 21-Hydroxylase in Zebrafish Causes Interrenal Hyperplasia
por: Eachus, Helen, et al.
Publicado: (2017)

CR6-interacting factor 1 is a key regulator in Aβ-induced mitochondrial disruption and pathogenesis of Alzheimer's disease
por: Byun, J, et al.
Publicado: (2015)

Disruption of the rice 4-DEOXYOROBANCHOL HYDROXYLASE unravels specific functions of canonical strigolactones
por: Chen, Guan-Ting Erica, et al.
Publicado: (2023)

Erratum: Benelli, R., et al. Aspartate-β-Hydroxylase: A Promising Target to Limit the Local Invasiveness of Colorectal Cancer. Cancers 2020, 12, 971
por: Benelli, Roberto, et al.
Publicado: (2020)

Protective effects of lycopene on mitochondrial oxidative injury and dysfunction in the liver of aflatoxin B(1)-exposed broilers
por: Wan, X.L., et al.
Publicado: (2021)

Aspartate Metabolism Facilitates IL-1β Production in Inflammatory Macrophages
por: Wang, Hao, et al.
Publicado: (2021)

Genetic diversity of tyrosine hydroxylase (TH) and dopamine β-hydroxylase (DBH) genes in cattle breeds
por: Lourenco-Jaramillo, Diana Lelidett, et al.
Publicado: (2012)

How Tyramine β-Hydroxylase Controls the Production of Octopamine, Modulating the Mobility of Beetles
por: Xu, Li, et al.
Publicado: (2018)

Genetic Disruption of Both Tryptophan Hydroxylase Genes Dramatically Reduces Serotonin and Affects Behavior in Models Sensitive to Antidepressants
por: Savelieva, Katerina V., et al.
Publicado: (2008)

Prolyl hydroxylase domain protein 3 and asparaginyl hydroxylase factor inhibiting HIF-1 levels are predictive of tumoral behavior and prognosis in hepatocellular carcinoma
por: Ma, Mingyang, et al.
Publicado: (2017)

Comparisons with Amyloid-β Reveal an Aspartate Residue That Stabilizes Fibrils of the Aortic Amyloid Peptide Medin
por: Davies, Hannah A., et al.
Publicado: (2015)

Clinical and Molecular Analysis of Four Patients With 11β-Hydroxylase Deficiency
por: Zhou, Qiaoli, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_q8c7eu3k36p68p6aeilbserihh