A Case of Fulminant Meningococcemia: It Is All in the Complement

Eculizumab is a novel monoclonal antibody that inhibits complement-mediated hemolysis in patients with paroxysmal nocturnal hemoglobinuria (PNH). Complement deficiency is a well-known risk factor for meningococcal infection. We describe a case of a young patient with PNH treated with eculizumab who...

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Detalles Bibliográficos
Autores principales: Hawkins, Kellie L., Hoffman, Mariah, Okuyama, Sonia, Rowan, Sarah E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541820/
https://www.ncbi.nlm.nih.gov/pubmed/28808592
http://dx.doi.org/10.1155/2017/6093695
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author Hawkins, Kellie L.
Hoffman, Mariah
Okuyama, Sonia
Rowan, Sarah E.
author_facet Hawkins, Kellie L.
Hoffman, Mariah
Okuyama, Sonia
Rowan, Sarah E.
author_sort Hawkins, Kellie L.
collection PubMed
description Eculizumab is a novel monoclonal antibody that inhibits complement-mediated hemolysis in patients with paroxysmal nocturnal hemoglobinuria (PNH). Complement deficiency is a well-known risk factor for meningococcal infection. We describe a case of a young patient with PNH treated with eculizumab who presented with a life-threatening case of nongroupable meningococcemia. As this new biologic agent becomes more widely prescribed, providers should be aware of the increased risk of meningococcemia. In addition to vaccination, providers may consider the use of oral penicillin for antibiotic prophylaxis against Neisseria meningitidis in these cases of functional complement deficiency.
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spelling pubmed-55418202017-08-14 A Case of Fulminant Meningococcemia: It Is All in the Complement Hawkins, Kellie L. Hoffman, Mariah Okuyama, Sonia Rowan, Sarah E. Case Rep Infect Dis Case Report Eculizumab is a novel monoclonal antibody that inhibits complement-mediated hemolysis in patients with paroxysmal nocturnal hemoglobinuria (PNH). Complement deficiency is a well-known risk factor for meningococcal infection. We describe a case of a young patient with PNH treated with eculizumab who presented with a life-threatening case of nongroupable meningococcemia. As this new biologic agent becomes more widely prescribed, providers should be aware of the increased risk of meningococcemia. In addition to vaccination, providers may consider the use of oral penicillin for antibiotic prophylaxis against Neisseria meningitidis in these cases of functional complement deficiency. Hindawi 2017 2017-07-20 /pmc/articles/PMC5541820/ /pubmed/28808592 http://dx.doi.org/10.1155/2017/6093695 Text en Copyright © 2017 Kellie L. Hawkins et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Hawkins, Kellie L.
Hoffman, Mariah
Okuyama, Sonia
Rowan, Sarah E.
A Case of Fulminant Meningococcemia: It Is All in the Complement
title A Case of Fulminant Meningococcemia: It Is All in the Complement
title_full A Case of Fulminant Meningococcemia: It Is All in the Complement
title_fullStr A Case of Fulminant Meningococcemia: It Is All in the Complement
title_full_unstemmed A Case of Fulminant Meningococcemia: It Is All in the Complement
title_short A Case of Fulminant Meningococcemia: It Is All in the Complement
title_sort case of fulminant meningococcemia: it is all in the complement
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541820/
https://www.ncbi.nlm.nih.gov/pubmed/28808592
http://dx.doi.org/10.1155/2017/6093695
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