ARID1A-mutated ovarian cancers depend on HDAC6 activity

ARID1A , encoding a subunit of the SWI/SNF chromatin-remodelling complex, is the most frequently mutated epigenetic regulator across all human cancers. ARID1A and TP53 mutations are typically mutually exclusive. Therapeutic approaches that correlate with this genetic characteristic remain to be expl...

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Detalles Bibliográficos
Autores principales: Bitler, Benjamin G., Wu, Shuai, Park, Pyoung Hwa, Hai, Yang, Aird, Katherine M., Wang, Yemin, Zhai, Yali, Kossenkov, Andrew V., Vara-Ailor, Ana, Rauscher, Frank J, Zou, Weiping, Speicher, David W., Huntsman, David G., Conejo-Garcia, Jose R., Cho, Kathleen R., Christianson, David W., Zhang, Rugang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541905/
https://www.ncbi.nlm.nih.gov/pubmed/28737768
http://dx.doi.org/10.1038/ncb3582

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541905/
https://www.ncbi.nlm.nih.gov/pubmed/28737768
http://dx.doi.org/10.1038/ncb3582

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