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Systemic Sympathoexcitation Was Associated with Paraventricular Hypothalamic Phosphorylation of Synaptic CaMKIIα and MAPK/ErK

Systemic administration of adrenergic agonist (Isoproterenol; ISOP) is known to facilitate cardiovascular changes associated with heart failure through an upregulation of cardiac toll-like receptor 4 (TLR4). Furthermore, previous studies have shown that cardiac tissue-specific deletion of TLR4 prote...

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Detalles Bibliográficos
Autores principales: Ogundele, Olalekan M., Rosa, Fernando A., Dharmakumar, Rohan, Lee, Charles C., Francis, Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541931/
https://www.ncbi.nlm.nih.gov/pubmed/28824368
http://dx.doi.org/10.3389/fnins.2017.00447