P-glycoprotein attenuates DNA repair activity in multidrug-resistant cells by acting through the Cbp-Csk-Src cascade

Recent studies have demonstrated that P-glycoprotein (P-gp) expression impairs DNA interstrand cross-linking agent-induced DNA repair efficiency in multidrug-resistant (MDR) cells. To date, the detailed molecular mechanisms underlying how P-gp interferes with Src activation and subsequent DNA repair...

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Detalles Bibliográficos
Autores principales: Lin, Li-Fang, Wu, Ming-Hsi, Pidugu, Vijaya Kumar, Ho, I-Ching, Su, Tsann-Long, Lee, Te-Chang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542168/
https://www.ncbi.nlm.nih.gov/pubmed/28178691
http://dx.doi.org/10.18632/oncotarget.15065

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542168/
https://www.ncbi.nlm.nih.gov/pubmed/28178691
http://dx.doi.org/10.18632/oncotarget.15065

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