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Error-prone DNA polymerase and oxidative stress increase the incidences of A to G mutations in tumors
Mutational processes for A→G mutations in tumors are not well understood. To uncover the mutational mechanisms, we analyzed molecular profiles of more than 9,000 tumor samples from The Cancer Genome Atlas (TCGA). The present study found that error-prone DNA polymerases were involved in stomach tumor...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Impact Journals LLC
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542174/ https://www.ncbi.nlm.nih.gov/pubmed/28582771 http://dx.doi.org/10.18632/oncotarget.13293 |