The effect of rapamycin, NVP-BEZ235, aspirin, and metformin on PI3K/AKT/mTOR signaling pathway of PIK3CA-related overgrowth spectrum (PROS)

The phosphatidylinositol 3-kinase (PI3K)/AKT/mTOR signaling pathway is critical for cellular growth and metabolism. Recently, mosaic or segmental overgrowth, a clinical condition caused by heterozygous somatic activating mutations in PIK3CA, was established as PIK3CA-related overgrowth spectrum (PRO...

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Detalles Bibliográficos
Autores principales: Suzuki, Yasuyo, Enokido, Yasushi, Yamada, Kenichiro, Inaba, Mie, Kuwata, Kumiko, Hanada, Naoki, Morishita, Tsuyoshi, Mizuno, Seiji, Wakamatsu, Nobuaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542201/
https://www.ncbi.nlm.nih.gov/pubmed/28525374
http://dx.doi.org/10.18632/oncotarget.17566

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542201/
https://www.ncbi.nlm.nih.gov/pubmed/28525374
http://dx.doi.org/10.18632/oncotarget.17566

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