Inhibition of stress-inducible HSP70 impairs mitochondrial proteostasis and function

Protein quality control is an important component of survival for all cells. The use of proteasome inhibitors for cancer therapy derives from the fact that tumor cells generally exhibit greater levels of proteotoxic stress than do normal cells, and thus cancer cells tend to be more sensitive to prot...

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Detalles Bibliográficos
Autores principales: Leu, Julia I-Ju, Barnoud, Thibaut, Zhang, Gao, Tian, Tian, Wei, Zhi, Herlyn, Meenhard, Murphy, Maureen E., George, Donna L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542216/
https://www.ncbi.nlm.nih.gov/pubmed/28484090
http://dx.doi.org/10.18632/oncotarget.17321

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542216/
https://www.ncbi.nlm.nih.gov/pubmed/28484090
http://dx.doi.org/10.18632/oncotarget.17321

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