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Inhibition of stress-inducible HSP70 impairs mitochondrial proteostasis and function
Protein quality control is an important component of survival for all cells. The use of proteasome inhibitors for cancer therapy derives from the fact that tumor cells generally exhibit greater levels of proteotoxic stress than do normal cells, and thus cancer cells tend to be more sensitive to prot...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Impact Journals LLC
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542216/ https://www.ncbi.nlm.nih.gov/pubmed/28484090 http://dx.doi.org/10.18632/oncotarget.17321 |