Targeted Disruption of V600E-Mutant BRAF Gene by CRISPR-Cpf1

BRAF-V600E (1799T > A) is one of the most frequently reported driver mutations in multiple types of cancers, and patients with such mutations could benefit from selectively inactivating the mutant allele. Near this mutation site, there are two TTTN and one NGG protospacer-adjacent motifs (PAMs) f...

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Detalles Bibliográficos
Autores principales: Yang, Meijia, Wei, Heng, Wang, Yuelong, Deng, Jiaojiao, Tang, Yani, Zhou, Liangxue, Guo, Gang, Tong, Aiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542387/
https://www.ncbi.nlm.nih.gov/pubmed/28918044
http://dx.doi.org/10.1016/j.omtn.2017.05.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542387/
https://www.ncbi.nlm.nih.gov/pubmed/28918044
http://dx.doi.org/10.1016/j.omtn.2017.05.009

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