Maternal obesity programs reduced leptin signaling in the pituitary and altered GH/IGF1 axis function leading to increased adiposity in adult sheep offspring

Studies in rodents highlight a role for leptin in stimulation of pituitary growth hormone (GH) secretion, with an impact on body composition regulation. We have reported that maternal obesity (MO) during ovine pregnancy results in hyperphagia, glucose-insulin dysregulation, increased adiposity, hype...

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Detalles Bibliográficos
Autores principales: Tuersunjiang, Nuermaimaiti, Odhiambo, John F., Shasa, Desiree R., Smith, Ashley M., Nathanielsz, Peter W., Ford, Stephen P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542597/
https://www.ncbi.nlm.nih.gov/pubmed/28771488
http://dx.doi.org/10.1371/journal.pone.0181795

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542597/
https://www.ncbi.nlm.nih.gov/pubmed/28771488
http://dx.doi.org/10.1371/journal.pone.0181795

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