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Hijacking of the O-GlcNAcZYME complex by the HTLV-1 Tax oncoprotein facilitates viral transcription

The viral Tax oncoprotein plays a key role in both Human T-cell lymphotropic virus type 1 (HTLV-1)-replication and HTLV-1-associated pathologies, notably adult T-cell leukemia. Tax governs the transcription from the viral 5’LTR, enhancing thereby its own expression, via the recruitment of dimers of...

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Detalles Bibliográficos
Autores principales: Groussaud, Damien, Khair, Mostafa, Tollenaere, Armelle I., Waast, Laetitia, Kuo, Mei-Shiue, Mangeney, Marianne, Martella, Christophe, Fardini, Yann, Coste, Solène, Souidi, Mouloud, Benit, Laurence, Pique, Claudine, Issad, Tarik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542696/
https://www.ncbi.nlm.nih.gov/pubmed/28742148
http://dx.doi.org/10.1371/journal.ppat.1006518