Mild Reductive Functionalization of Amides into N‐Sulfonylformamidines

The development of a protocol for the reductive functionalization of amides into N‐sulfonylformamidines is reported. The one‐pot procedure is based on a mild catalytic reduction of tertiary amides into the corresponding enamines by the use of Mo(CO)(6) (molybdenum hexacarbonyl) and TMDS (1,1,3,3‐tet...

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Detalles Bibliográficos
Autores principales: Trillo, Paz, Slagbrand, Tove, Tinnis, Fredrik, Adolfsson, Hans
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542752/
https://www.ncbi.nlm.nih.gov/pubmed/28794940
http://dx.doi.org/10.1002/open.201700087
Descripción
Sumario:The development of a protocol for the reductive functionalization of amides into N‐sulfonylformamidines is reported. The one‐pot procedure is based on a mild catalytic reduction of tertiary amides into the corresponding enamines by the use of Mo(CO)(6) (molybdenum hexacarbonyl) and TMDS (1,1,3,3‐tetramethyldisiloxane). The formed enamines were allowed to react with sulfonyl azides to give the target compounds in moderate to good yields.

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