Mild Reductive Functionalization of Amides into N‐Sulfonylformamidines

The development of a protocol for the reductive functionalization of amides into N‐sulfonylformamidines is reported. The one‐pot procedure is based on a mild catalytic reduction of tertiary amides into the corresponding enamines by the use of Mo(CO)(6) (molybdenum hexacarbonyl) and TMDS (1,1,3,3‐tet...

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Detalles Bibliográficos
Autores principales: Trillo, Paz, Slagbrand, Tove, Tinnis, Fredrik, Adolfsson, Hans
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542752/
https://www.ncbi.nlm.nih.gov/pubmed/28794940
http://dx.doi.org/10.1002/open.201700087
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author Trillo, Paz
Slagbrand, Tove
Tinnis, Fredrik
Adolfsson, Hans
author_facet Trillo, Paz
Slagbrand, Tove
Tinnis, Fredrik
Adolfsson, Hans
author_sort Trillo, Paz
collection PubMed
description The development of a protocol for the reductive functionalization of amides into N‐sulfonylformamidines is reported. The one‐pot procedure is based on a mild catalytic reduction of tertiary amides into the corresponding enamines by the use of Mo(CO)(6) (molybdenum hexacarbonyl) and TMDS (1,1,3,3‐tetramethyldisiloxane). The formed enamines were allowed to react with sulfonyl azides to give the target compounds in moderate to good yields.
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spelling pubmed-55427522017-08-09 Mild Reductive Functionalization of Amides into N‐Sulfonylformamidines Trillo, Paz Slagbrand, Tove Tinnis, Fredrik Adolfsson, Hans ChemistryOpen Communications The development of a protocol for the reductive functionalization of amides into N‐sulfonylformamidines is reported. The one‐pot procedure is based on a mild catalytic reduction of tertiary amides into the corresponding enamines by the use of Mo(CO)(6) (molybdenum hexacarbonyl) and TMDS (1,1,3,3‐tetramethyldisiloxane). The formed enamines were allowed to react with sulfonyl azides to give the target compounds in moderate to good yields. John Wiley and Sons Inc. 2017-07-03 /pmc/articles/PMC5542752/ /pubmed/28794940 http://dx.doi.org/10.1002/open.201700087 Text en © 2017 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Communications
Trillo, Paz
Slagbrand, Tove
Tinnis, Fredrik
Adolfsson, Hans
Mild Reductive Functionalization of Amides into N‐Sulfonylformamidines
title Mild Reductive Functionalization of Amides into N‐Sulfonylformamidines
title_full Mild Reductive Functionalization of Amides into N‐Sulfonylformamidines
title_fullStr Mild Reductive Functionalization of Amides into N‐Sulfonylformamidines
title_full_unstemmed Mild Reductive Functionalization of Amides into N‐Sulfonylformamidines
title_short Mild Reductive Functionalization of Amides into N‐Sulfonylformamidines
title_sort mild reductive functionalization of amides into n‐sulfonylformamidines
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542752/
https://www.ncbi.nlm.nih.gov/pubmed/28794940
http://dx.doi.org/10.1002/open.201700087
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