Eliminating HIV-1 Packaging Sequences from Lentiviral Vector Proviruses Enhances Safety and Expedites Gene Transfer for Gene Therapy

Lentiviral vector genomic RNA requires sequences that partially overlap wild-type HIV-1 gag and env genes for packaging into vector particles. These HIV-1 packaging sequences constitute 19.6% of the wild-type HIV-1 genome and contain functional cis elements that potentially compromise clinical safet...

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Detalles Bibliográficos
Autores principales: Vink, Conrad A., Counsell, John R., Perocheau, Dany P., Karda, Rajvinder, Buckley, Suzanne M.K., Brugman, Martijn H., Galla, Melanie, Schambach, Axel, McKay, Tristan R., Waddington, Simon N., Howe, Steven J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542766/
https://www.ncbi.nlm.nih.gov/pubmed/28550974
http://dx.doi.org/10.1016/j.ymthe.2017.04.028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542766/
https://www.ncbi.nlm.nih.gov/pubmed/28550974
http://dx.doi.org/10.1016/j.ymthe.2017.04.028

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