Renal Protection Mediated by Hypoxia Inducible Factor-1α Depends on Proangiogenesis Function of miR-21 by Targeting Thrombospondin 1

BACKGROUND: Angiogenesis contributes to the repair process after renal ischemia/reperfusion (I/R) injury. In the present study, we tested the role of miR-21 in the angiogenesis induced by hypoxia inducible factor (HIF)-1α through inhibiting a predicted target gene thrombospondin 1 (TSP-1). METHODS:...

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Detalles Bibliográficos
Autores principales: Xu, Xialian, Song, Nana, Zhang, Xue, Jiao, Xiaoyan, Hu, Jiachang, Liang, Mingyu, Teng, Jie, Ding, Xiaoqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2017
Materias:
Original Basic Science—General
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542793/
https://www.ncbi.nlm.nih.gov/pubmed/28737660
http://dx.doi.org/10.1097/TP.0000000000001501

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542793/
https://www.ncbi.nlm.nih.gov/pubmed/28737660
http://dx.doi.org/10.1097/TP.0000000000001501

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