Selected mitochondrial DNA landscapes activate the SIRT3 axis of the UPR(mt) to promote metastasis

By causing mitochondrial DNA (mtDNA) mutations and oxidation of mitochondrial proteins, reactive oxygen species (ROS) leads to perturbations in mitochondrial proteostasis. Several studies have linked mtDNA mutations to metastasis of cancer cells but the nature of the mtDNA species involved remains u...

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Detalles Bibliográficos
Autores principales: Kenny, T C, Hart, P, Ragazzi, M, Sersinghe, M, Chipuk, J, Sagar, M A K, Eliceiri, K W, LaFramboise, T, Grandhi, S, Santos, J, Riar, A K, Papa, L, D'Aurello, M, Manfredi, G, Bonini, M G, Germain, D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542861/
https://www.ncbi.nlm.nih.gov/pubmed/28368421
http://dx.doi.org/10.1038/onc.2017.52

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542861/
https://www.ncbi.nlm.nih.gov/pubmed/28368421
http://dx.doi.org/10.1038/onc.2017.52

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