Mechanistic and structural basis for activation of cardiac myosin force production by omecamtiv mecarbil

Omecamtiv mecarbil is a selective, small-molecule activator of cardiac myosin that is being developed as a potential treatment for heart failure with reduced ejection fraction. Here we determine the crystal structure of cardiac myosin in the pre-powerstroke state, the most relevant state suggested b...

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Detalles Bibliográficos
Autores principales: Planelles-Herrero, Vicente J., Hartman, James J., Robert-Paganin, Julien, Malik, Fady I., Houdusse, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543065/
https://www.ncbi.nlm.nih.gov/pubmed/28775348
http://dx.doi.org/10.1038/s41467-017-00176-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543065/
https://www.ncbi.nlm.nih.gov/pubmed/28775348
http://dx.doi.org/10.1038/s41467-017-00176-5

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