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Mechanistic and structural basis for activation of cardiac myosin force production by omecamtiv mecarbil
Omecamtiv mecarbil is a selective, small-molecule activator of cardiac myosin that is being developed as a potential treatment for heart failure with reduced ejection fraction. Here we determine the crystal structure of cardiac myosin in the pre-powerstroke state, the most relevant state suggested b...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543065/ https://www.ncbi.nlm.nih.gov/pubmed/28775348 http://dx.doi.org/10.1038/s41467-017-00176-5 |