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Isocitrate dehydrogenases in physiology and cancer: biochemical and molecular insight
Isocitrate dehydrogenases play important roles in cellular metabolism and cancer. This review will discuss how the roles of isoforms 1 and 2 in normal cell and cancer metabolism are distinct from those of isoform 3. It will also explain why, unlike 1 and 2, mutations in isoform 3 in tumor are not li...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543436/ https://www.ncbi.nlm.nih.gov/pubmed/28785398 http://dx.doi.org/10.1186/s13578-017-0165-3 |