Modeling tumor cell adaptations to hypoxia in multicellular tumor spheroids

Under hypoxic conditions, tumor cells undergo a series of adaptations that promote evolution of a more aggressive tumor phenotype including the activation of DNA damage repair proteins, altered metabolism, and decreased proliferation. Together these changes mitigate the negative impact of oxygen dep...

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Detalles Bibliográficos
Autores principales: Riffle, Stephen, Hegde, Rashmi S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543535/
https://www.ncbi.nlm.nih.gov/pubmed/28774341
http://dx.doi.org/10.1186/s13046-017-0570-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543535/
https://www.ncbi.nlm.nih.gov/pubmed/28774341
http://dx.doi.org/10.1186/s13046-017-0570-9

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