microRNA dysregulation in polyglutamine toxicity of TATA-box binding protein is mediated through STAT1 in mouse neuronal cells

BACKGROUND: Polyglutamine diseases constitute a class of neurodegenerative disorders associated with expansion of the cytosine-adenine-guanine (CAG) triplet, in protein coding genes. Expansion of a polyglutamine tract in the N-terminal of TBP is the causal mutation in SCA17. Brain sections of patien...

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Detalles Bibliográficos
Autores principales: Roshan, Reema, Choudhary, Ashwani, Bhambri, Aksheev, Bakshi, Bhawani, Ghosh, Tanay, Pillai, Beena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543588/
https://www.ncbi.nlm.nih.gov/pubmed/28774347
http://dx.doi.org/10.1186/s12974-017-0925-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543588/
https://www.ncbi.nlm.nih.gov/pubmed/28774347
http://dx.doi.org/10.1186/s12974-017-0925-3

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