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microRNA dysregulation in polyglutamine toxicity of TATA-box binding protein is mediated through STAT1 in mouse neuronal cells

BACKGROUND: Polyglutamine diseases constitute a class of neurodegenerative disorders associated with expansion of the cytosine-adenine-guanine (CAG) triplet, in protein coding genes. Expansion of a polyglutamine tract in the N-terminal of TBP is the causal mutation in SCA17. Brain sections of patien...

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Detalles Bibliográficos
Autores principales:	Roshan, Reema, Choudhary, Ashwani, Bhambri, Aksheev, Bakshi, Bhawani, Ghosh, Tanay, Pillai, Beena
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543588/ https://www.ncbi.nlm.nih.gov/pubmed/28774347 http://dx.doi.org/10.1186/s12974-017-0925-3

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