Cargando…

Evolution of the p53-MDM2 pathway

BACKGROUND: The p53 signalling pathway, which controls cell fate, has been extensively studied due to its prominent role in tumor development. The pathway includes the tumor supressor protein p53, its vertebrate paralogs p63 and p73, and their negative regulators MDM2 and MDM4. The p53/p63/p73-MDM s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Åberg, Emma, Saccoccia, Fulvio, Grabherr, Manfred, Ore, Wai Ying Josefin, Jemth, Per, Hultqvist, Greta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543598/ https://www.ncbi.nlm.nih.gov/pubmed/28774266 http://dx.doi.org/10.1186/s12862-017-1023-y

Ejemplares similares

Evolution of affinity between p53 transactivation domain and MDM2 across the animal kingdom demonstrates high plasticity of motif‐mediated interactions
por: Mihalič, Filip, et al.
Publicado: (2023)

Emergence and evolution of an interaction between intrinsically disordered proteins
por: Hultqvist, Greta, et al.
Publicado: (2017)

The MDM2-p53 pathway revisited
por: Nag, Subhasree, et al.
Publicado: (2013)

The RP-Mdm2-p53 Pathway and Tumorigenesis
por: Miliani de Marval, Paula L., et al.
Publicado: (2011)

Targeting the MDM2-p53 pathway in dedifferentiated liposarcoma
por: Traweek, Raymond S., et al.
Publicado: (2022)

Structural Basis of Competitive Recognition of p53 and MDM2 by HAUSP/USP7: Implications for the Regulation of the p53–MDM2 Pathway
por: Hu, Min, et al.
Publicado: (2006)

Energetic Landscape of MDM2-p53 Interactions by Computational Mutagenesis of the MDM2-p53 Interaction
por: Thayer, Kelly M., et al.
Publicado: (2016)

The Role of Backbone Hydrogen Bonds in the Transition State for Protein Folding of a PDZ Domain
por: Pedersen, Søren W., et al.
Publicado: (2014)

Regulation of kidney development by the Mdm2/Mdm4–p53 axis
por: El-Dahr, Samir, et al.
Publicado: (2017)

Regulation of p53: a collaboration between Mdm2 and MdmX
por: Pei, Dongsheng, et al.
Publicado: (2012)

Detection of P53 and Mdm2 in vitiligo
por: Wiwanitkit, Viroj
Publicado: (2013)

Novel Allosteric Mechanism of Dual p53/MDM2 and p53/MDM4 Inhibition by a Small Molecule
por: Grinkevich, Vera V., et al.
Publicado: (2022)

Benzimidazoles Downregulate Mdm2 and MdmX and Activate p53 in MdmX Overexpressing Tumor Cells
por: Mrkvová, Zuzana, et al.
Publicado: (2019)

Regulation of the MDM2‐p53 pathway by the ubiquitin ligase HERC2
por: García‐Cano, Jesús, et al.
Publicado: (2019)

The Dual Interactions of p53 with MDM2 and p300: Implications for the Design of MDM2 Inhibitors
por: Kannan, Srinivasaraghavan, et al.
Publicado: (2019)

p90RSK Regulates p53 Pathway by MDM2 Phosphorylation in Thyroid Tumors
por: Maietta, Immacolata, et al.
Publicado: (2022)

Controlling the Mdm2-Mdmx-p53 Circuit
por: Waning, David L., et al.
Publicado: (2010)

Immunohistochemical detection of P53 and Mdm2 in vitiligo
por: Bakry, Ola A., et al.
Publicado: (2012)

Heterogeneous Hydration of p53/MDM2 Complex
por: Guo, Zuojun, et al.
Publicado: (2014)

Reactivation of p53 via MDM2 inhibition
por: Kim, E S, et al.
Publicado: (2015)

Fortifying p53 – beyond Mdm2 inhibitors
por: Sriraman, Anusha, et al.
Publicado: (2016)

Structure and dynamics conspire in the evolution of affinity between intrinsically disordered proteins
por: Jemth, Per, et al.
Publicado: (2018)

The MDM2-p53 pathway is involved in preconditioning-induced neuronal tolerance to ischemia
por: Vecino, Rebeca, et al.
Publicado: (2018)

The SWIB/MDM2 motif of UBE4B activates the p53 pathway
por: Wu, H. Helena, et al.
Publicado: (2023)

Natural products targeting the p53-MDM2 pathway and mutant p53: Recent advances and implications in cancer medicine
por: Qin, Jiang-Jiang, et al.
Publicado: (2018)

Simultaneous measurement of p53:Mdm2 and p53:Mdm4 protein-protein interactions in whole cells using fluorescence labelled foci
por: Frosi, Y., et al.
Publicado: (2019)

The p53–Mdm2 interaction and the E3 ligase activity of Mdm2/Mdm4 are conserved from lampreys to humans
por: Coffill, Cynthia R., et al.
Publicado: (2016)

p53 Phosphomimetics Preserve Transient Secondary Structure but Reduce Binding to Mdm2 and MdmX
por: Levy, Robin, et al.
Publicado: (2019)

Artificial Macrocycles as Potent p53–MDM2 Inhibitors
por: Estrada-Ortiz, Natalia, et al.
Publicado: (2017)

Explaining oscillations and variability in the p53-Mdm2 system
por: Proctor, Carole J, et al.
Publicado: (2008)

Targeting the p53–MDM2 interaction to treat cancer
por: Klein, C, et al.
Publicado: (2004)

The Role of p53 and MDM2 in Head and Neck Cancer
por: Denaro, N., et al.
Publicado: (2011)

p53 AND MDM2 PROTEIN EXPRESSION IN ACTINIC CHEILITIS
por: de Freitas, Maria da Conceição Andrade, et al.
Publicado: (2008)

Rewired Notch/p53 by Numb’ing Mdm2
por: Kim, Hyungsoo, et al.
Publicado: (2018)

Anatomy of Mdm2 and Mdm4 in evolution
por: Tan, Ban Xiong, et al.
Publicado: (2017)

Regulation of the MDM2-p53 pathway by the nucleolar protein CSIG in response to nucleolar stress
por: Xie, Nan, et al.
Publicado: (2016)

Tumor-specific signaling to p53 is mimicked by Mdm2 inactivation in zebrafish: insights from mdm2 and mdm4 mutant zebrafish
por: Chua, J S, et al.
Publicado: (2015)

SCYL1BP1 modulates neurite outgrowth and regeneration by regulating the Mdm2/p53 pathway
por: Liu, Yonghua, et al.
Publicado: (2012)

Targeting p53–MDM2 interaction by small-molecule inhibitors: learning from MDM2 inhibitors in clinical trials
por: Zhu, Haohao, et al.
Publicado: (2022)

ODP281 JDP2 Interacts with MDM2 and Decreases MDM2-Mediated p53 Repression
por: Yang, William, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_p0u9sfupceiqhttt12om7bd48c