An ROR1 bi-specific T-cell engager provides effective targeting and cytotoxicity against a range of solid tumors

We have developed a humanized bi-specific T-cell engager (BiTE) targeting receptor tyrosine kinase-like orphan receptor 1 (ROR1), a cell surface antigen present on a range of malignancies and cancer-initiating cells. Focusing initially on pancreatic cancer, we demonstrated that our ROR1 BiTE results...

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Detalles Bibliográficos
Autores principales: Gohil, Satyen Harish, Paredes-Moscosso, Solange Rosa, Harrasser, Micaela, Vezzalini, Marzia, Scarpa, Aldo, Morris, Emma, Davidoff, Andrew M., Sorio, Claudio, Nathwani, Amit Chunilal, Della Peruta, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543882/
https://www.ncbi.nlm.nih.gov/pubmed/28811962
http://dx.doi.org/10.1080/2162402X.2017.1326437

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543882/
https://www.ncbi.nlm.nih.gov/pubmed/28811962
http://dx.doi.org/10.1080/2162402X.2017.1326437

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