Alteration of Wnt5a expression and of the non-canonical Wnt/PCP and Wnt/PKC-Ca(2+) pathways in human osteoarthritis osteoblasts

OBJECTIVE: Clinical and in vitro studies suggest that subchondral bone sclerosis due to abnormal osteoblasts (Ob) is involved in the progression and/or onset of osteoarthritis (OA). Human Ob isolated from sclerotic subchondral OA bone tissue show an altered phenotype, a decreased canonical Wnt/β-cat...

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Detalles Bibliográficos
Autores principales: Martineau, Xavier, Abed, Élie, Martel-Pelletier, Johanne, Pelletier, Jean-Pierre, Lajeunesse, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544184/
https://www.ncbi.nlm.nih.gov/pubmed/28777797
http://dx.doi.org/10.1371/journal.pone.0180711

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544184/
https://www.ncbi.nlm.nih.gov/pubmed/28777797
http://dx.doi.org/10.1371/journal.pone.0180711

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