Cargando…
Alteration of Wnt5a expression and of the non-canonical Wnt/PCP and Wnt/PKC-Ca(2+) pathways in human osteoarthritis osteoblasts
OBJECTIVE: Clinical and in vitro studies suggest that subchondral bone sclerosis due to abnormal osteoblasts (Ob) is involved in the progression and/or onset of osteoarthritis (OA). Human Ob isolated from sclerotic subchondral OA bone tissue show an altered phenotype, a decreased canonical Wnt/β-cat...
| Autores principales: | , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2017
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544184/ https://www.ncbi.nlm.nih.gov/pubmed/28777797 http://dx.doi.org/10.1371/journal.pone.0180711 |