Regulation of Gli ciliary localization and Hedgehog signaling by the PY-NLS/karyopherin-β2 nuclear import system

Hedgehog (Hh) signaling in vertebrates depends on primary cilia. Upon stimulation, Hh pathway components, including Gli transcription factors, accumulate at primary cilia to transduce the Hh signal, but the mechanisms underlying their ciliary targeting remains largely unknown. Here, we show that the...

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Detalles Bibliográficos
Autores principales: Han, Yuhong, Xiong, Yue, Shi, Xuanming, Wu, Jiang, Zhao, Yun, Jiang, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544186/
https://www.ncbi.nlm.nih.gov/pubmed/28777795
http://dx.doi.org/10.1371/journal.pbio.2002063

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544186/
https://www.ncbi.nlm.nih.gov/pubmed/28777795
http://dx.doi.org/10.1371/journal.pbio.2002063

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