Structural pathway of regulated substrate transfer and threading through an Hsp100 disaggregase

Refolding aggregated proteins is essential in combating cellular proteotoxic stress. Together with Hsp70, Hsp100 chaperones, including Escherichia coli ClpB, form a powerful disaggregation machine that threads aggregated polypeptides through the central pore of tandem adenosine triphosphatase (ATPas...

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Detalles Bibliográficos
Autores principales: Deville, Célia, Carroni, Marta, Franke, Kamila B., Topf, Maya, Bukau, Bernd, Mogk, Axel, Saibil, Helen R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544394/
https://www.ncbi.nlm.nih.gov/pubmed/28798962
http://dx.doi.org/10.1126/sciadv.1701726

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544394/
https://www.ncbi.nlm.nih.gov/pubmed/28798962
http://dx.doi.org/10.1126/sciadv.1701726

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