Quantitative proteomics screen identifies a substrate repertoire of rhomboid protease RHBDL2 in human cells and implicates it in epithelial homeostasis

Rhomboids are intramembrane serine proteases conserved in all kingdoms of life. They regulate epidermal growth factor receptor signalling in Drosophila by releasing signalling ligands from their transmembrane tethers. Their functions in mammals are poorly understood, in part because of the lack of e...

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Detalles Bibliográficos
Autores principales: Johnson, Nicholas, Březinová, Jana, Stephens, Elaine, Burbridge, Emma, Freeman, Matthew, Adrain, Colin, Strisovsky, Kvido
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544772/
https://www.ncbi.nlm.nih.gov/pubmed/28779096
http://dx.doi.org/10.1038/s41598-017-07556-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544772/
https://www.ncbi.nlm.nih.gov/pubmed/28779096
http://dx.doi.org/10.1038/s41598-017-07556-3

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