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Schizophrenia-like phenotypes in mice with NMDA receptor ablation in intralaminar thalamic nucleus cells and gene therapy-based reversal in adults

In understanding the mechanism of schizophrenia pathogenesis, a significant finding is that drug abuse of phencyclidine or its analog ketamine causes symptoms similar to schizophrenia. Such drug effects are triggered even by administration at post-adolescent stages. Both drugs are N-methyl-d-asparta...

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Detalles Bibliográficos
Autores principales: Yasuda, K, Hayashi, Y, Yoshida, T, Kashiwagi, M, Nakagawa, N, Michikawa, T, Tanaka, M, Ando, R, Huang, A, Hosoya, T, McHugh, T J, Kuwahara, M, Itohara, S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5545645/
https://www.ncbi.nlm.nih.gov/pubmed/28244984
http://dx.doi.org/10.1038/tp.2017.19