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Involvement of the agmatinergic system in the depressive-like phenotype of the Crtc1 knockout mouse model of depression

Recent studies implicate the arginine-decarboxylation product agmatine in mood regulation. Agmatine has antidepressant properties in rodent models of depression, and agmatinase (Agmat), the agmatine-degrading enzyme, is upregulated in the brains of mood disorder patients. We have previously shown th...

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Detalles Bibliográficos
Autores principales: Meylan, E M, Breuillaud, L, Seredenina, T, Magistretti, P J, Halfon, O, Luthi-Carter, R, Cardinaux, J-R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5545706/
https://www.ncbi.nlm.nih.gov/pubmed/27404284
http://dx.doi.org/10.1038/tp.2016.116