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Histamine H3R receptor activation in the dorsal striatum triggers stereotypies in a mouse model of tic disorders

Tic disorders affect ~5% of the population and are frequently comorbid with obsessive-compulsive disorder, autism, and attention deficit disorder. Histamine dysregulation has been identified as a rare genetic cause of tic disorders; mice with a knockout of the histidine decarboxylase (Hdc) gene repr...

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Detalles Bibliográficos
Autores principales: Rapanelli, M, Frick, L, Pogorelov, V, Ohtsu, H, Bito, H, Pittenger, C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5545743/
https://www.ncbi.nlm.nih.gov/pubmed/28117842
http://dx.doi.org/10.1038/tp.2016.290