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Of Mice and Men: Comparative Analysis of Neuro-Inflammatory Mechanisms in Human and Mouse Using Cause-and-Effect Models
Perturbance in inflammatory pathways have been identified as one of the major factors which leads to neurodegenerative diseases (NDD). Owing to the limited access of human brain tissues and the immense complexity of the brain, animal models, specifically mouse models, play a key role in advancing th...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
IOS Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5545904/ https://www.ncbi.nlm.nih.gov/pubmed/28731442 http://dx.doi.org/10.3233/JAD-170255 |
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author | Kodamullil, Alpha Tom Iyappan, Anandhi Karki, Reagon Madan, Sumit Younesi, Erfan Hofmann-Apitius, Martin |
author_facet | Kodamullil, Alpha Tom Iyappan, Anandhi Karki, Reagon Madan, Sumit Younesi, Erfan Hofmann-Apitius, Martin |
author_sort | Kodamullil, Alpha Tom |
collection | PubMed |
description | Perturbance in inflammatory pathways have been identified as one of the major factors which leads to neurodegenerative diseases (NDD). Owing to the limited access of human brain tissues and the immense complexity of the brain, animal models, specifically mouse models, play a key role in advancing the NDD field. However, many of these mouse models fail to reproduce the clinical manifestations and end points of the disease. NDD drugs, which passed the efficacy test in mice, were repeatedly not successful in clinical trials. There are numerous studies which are supporting and opposing the applicability of mouse models in neuroinflammation and NDD. In this paper, we assessed to what extend a mouse can mimic the cellular and molecular interactions in humans at a mechanism level. Based on our mechanistic modeling approach, we investigate the failure of a neuroinflammation targeted drug in the late phases of clinical trials based on the comparative analyses between the two species. |
format | Online Article Text |
id | pubmed-5545904 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | IOS Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-55459042017-08-16 Of Mice and Men: Comparative Analysis of Neuro-Inflammatory Mechanisms in Human and Mouse Using Cause-and-Effect Models Kodamullil, Alpha Tom Iyappan, Anandhi Karki, Reagon Madan, Sumit Younesi, Erfan Hofmann-Apitius, Martin J Alzheimers Dis Research Article Perturbance in inflammatory pathways have been identified as one of the major factors which leads to neurodegenerative diseases (NDD). Owing to the limited access of human brain tissues and the immense complexity of the brain, animal models, specifically mouse models, play a key role in advancing the NDD field. However, many of these mouse models fail to reproduce the clinical manifestations and end points of the disease. NDD drugs, which passed the efficacy test in mice, were repeatedly not successful in clinical trials. There are numerous studies which are supporting and opposing the applicability of mouse models in neuroinflammation and NDD. In this paper, we assessed to what extend a mouse can mimic the cellular and molecular interactions in humans at a mechanism level. Based on our mechanistic modeling approach, we investigate the failure of a neuroinflammation targeted drug in the late phases of clinical trials based on the comparative analyses between the two species. IOS Press 2017-07-29 /pmc/articles/PMC5545904/ /pubmed/28731442 http://dx.doi.org/10.3233/JAD-170255 Text en © 2017 – IOS Press and the authors. All rights reserved https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) License (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Research Article Kodamullil, Alpha Tom Iyappan, Anandhi Karki, Reagon Madan, Sumit Younesi, Erfan Hofmann-Apitius, Martin Of Mice and Men: Comparative Analysis of Neuro-Inflammatory Mechanisms in Human and Mouse Using Cause-and-Effect Models |
title | Of Mice and Men: Comparative Analysis of Neuro-Inflammatory Mechanisms in Human and Mouse Using Cause-and-Effect Models |
title_full | Of Mice and Men: Comparative Analysis of Neuro-Inflammatory Mechanisms in Human and Mouse Using Cause-and-Effect Models |
title_fullStr | Of Mice and Men: Comparative Analysis of Neuro-Inflammatory Mechanisms in Human and Mouse Using Cause-and-Effect Models |
title_full_unstemmed | Of Mice and Men: Comparative Analysis of Neuro-Inflammatory Mechanisms in Human and Mouse Using Cause-and-Effect Models |
title_short | Of Mice and Men: Comparative Analysis of Neuro-Inflammatory Mechanisms in Human and Mouse Using Cause-and-Effect Models |
title_sort | of mice and men: comparative analysis of neuro-inflammatory mechanisms in human and mouse using cause-and-effect models |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5545904/ https://www.ncbi.nlm.nih.gov/pubmed/28731442 http://dx.doi.org/10.3233/JAD-170255 |
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