Cargando…

Mitochondrial ASncmtRNA-1 and ASncmtRNA-2 as potent targets to inhibit tumor growth and metastasis in the RenCa murine renal adenocarcinoma model

Knockdown of antisense noncoding mitochondrial RNAs (ASncmtRNAs) induces apoptosis in several human and mouse tumor cell lines, but not normal cells, suggesting this approach for a selective therapy against different types of cancer. Here we show that in vitro knockdown of murine ASncmtRNAs induces...

Descripción completa

Detalles Bibliográficos
Autores principales:	Borgna, Vincenzo, Villegas, Jaime, Burzio, Verónica A., Belmar, Sebastián, Araya, Mariela, Jeldes, Emanuel, Lobos-González, Lorena, Silva, Verónica, Villota, Claudio, Oliveira-Cruz, Luciana, Lopez, Constanza, Socias, Teresa, Castillo, Octavio, Burzio, Luis O.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Priority Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546434/ https://www.ncbi.nlm.nih.gov/pubmed/28620146 http://dx.doi.org/10.18632/oncotarget.18460

Ejemplares similares

Exosomes released upon mitochondrial ASncmtRNA knockdown reduce tumorigenic properties of malignant breast cancer cells
por: Lobos-González, Lorena, et al.
Publicado: (2020)

Inverse Modulation of Aurora Kinase A and Topoisomerase IIα in Normal and Tumor Breast Cells upon Knockdown of Mitochondrial ASncmtRNA
por: Bendek, Maximiliano F., et al.
Publicado: (2023)

Long non-coding RNA ASncmtRNA-2 is upregulated in diabetic kidneys and high glucose-treated mesangial cells
por: Gao, Yan, et al.
Publicado: (2017)

HPV-18 E2 protein downregulates antisense noncoding mitochondrial RNA-2, delaying replicative senescence of human keratinocytes
por: Villota, Claudio, et al.
Publicado: (2018)

Targeting antisense mitochondrial noncoding RNAs induces bladder cancer cell death and inhibition of tumor growth through reduction of survival and invasion factors
por: Borgna, Vincenzo, et al.
Publicado: (2020)

Down-regulation of the Antisense Mitochondrial Non-coding RNAs (ncRNAs) Is a Unique Vulnerability of Cancer Cells and a Potential Target for Cancer Therapy
por: Vidaurre, Soledad, et al.
Publicado: (2014)

Targeting antisense mitochondrial ncRNAs inhibits murine melanoma tumor growth and metastasis through reduction in survival and invasion factors
por: Lobos-González, Lorena, et al.
Publicado: (2016)

Determination of the differential expression of mitochondrial long non-coding RNAs as a noninvasive diagnosis of bladder cancer
por: Rivas, Alexis, et al.
Publicado: (2012)

Different cancers, same target?
por: Villegas, Jaime, et al.
Publicado: (2017)

Mitochondrial ncRNA targeting induces cell cycle arrest and tumor growth inhibition of MDA-MB-231 breast cancer cells through reduction of key cell cycle progression factors
por: Fitzpatrick, Christopher, et al.
Publicado: (2019)

Expression of a novel non-coding mitochondrial RNA in human proliferating cells
por: Villegas, Jaime, et al.
Publicado: (2007)

Expression of Mitochondrial Non-coding RNAs (ncRNAs) Is Modulated by High Risk Human Papillomavirus (HPV) Oncogenes
por: Villota, Claudio, et al.
Publicado: (2012)

Antisense noncoding mitochondrial RNA-2 gives rise to miR-4485-3p by Dicer processing in vitro
por: Farfán, Nicole, et al.
Publicado: (2021)

Renca : folklore puntano.
Publicado: (1958)

Trafficking of activated lymphocytes into the RENCA tumour microcirculation in vivo in mice.
por: Brown, N. J., et al.
Publicado: (1997)

Foxp3 Expression in Macrophages Associated with RENCA Tumors in Mice
por: Devaud, Christel, et al.
Publicado: (2014)

Comparison of SARS-CoV-2 RT-PCR on a high-throughput molecular diagnostic platform and the cobas SARS-CoV-2 test for the diagnostic of COVID-19 on various clinical samples
por: Opota, Onya, et al.
Publicado: (2020)

RNA nanoparticle as a vector for targeted siRNA delivery into glioblastoma mouse model
por: Lee, Tae Jin, et al.
Publicado: (2015)

Tissue- and age-dependent expression of RNA-binding proteins that influence mRNA turnover and translation
por: Masuda, Kiyoshi, et al.
Publicado: (2009)

Editorial: Role of mitochondria-associated non-coding RNAs in intracellular communication
por: Burzio, Veronica A., et al.
Publicado: (2022)

A genome-wide miRNA screen revealed miR-603 as a MGMT-regulating miRNA in glioblastomas
por: Kushwaha, Deepa, et al.
Publicado: (2014)

Caveolin-1 is a risk factor for postsurgery metastasis in preclinical melanoma models
por: Lobos-Gonzalez, Lorena, et al.
Publicado: (2014)

microRNA expression profiling identifies a four microRNA signature as a novel diagnostic and prognostic biomarker in triple negative breast cancers
por: Gasparini, Pierluigi, et al.
Publicado: (2014)

Trafficking of ‘immune’ CD4(+)/CD8(+) T-lymphocytes into the RENCA tumour microcirculation in vivo in mice
por: Ali, S A, et al.
Publicado: (2000)

Colección Ren Bonian

Prognostic relevance of miRNA-155 methylation in anaplastic glioma
por: Schliesser, Maximilian Georg, et al.
Publicado: (2016)

Novel lincRNA SLINKY is a prognostic biomarker in kidney cancer
por: Gong, Xue, et al.
Publicado: (2017)

Upregulation of long noncoding RNA MIAT in aggressive form of chronic lymphocytic leukemias
por: Sattari, Arash, et al.
Publicado: (2016)

MicroRNA dysregulation and esophageal cancer development depend on the extent of zinc dietary deficiency
por: Fong, Louise Y., et al.
Publicado: (2016)

Loss of p53-inducible long non-coding RNA LINC01021 increases chemosensitivity
por: Kaller, Markus, et al.
Publicado: (2017)

MicroRNA-224 is implicated in lung cancer pathogenesis through targeting caspase-3 and caspase-7
por: Cui, Ri, et al.
Publicado: (2015)

MicroRNA-200, associated with metastatic breast cancer, promotes traits of mammary luminal progenitor cells
por: Sánchez-Cid, Lourdes, et al.
Publicado: (2017)

Development of a predictive miRNA signature for breast cancer risk among high-risk women
por: Farina, Nicholas H., et al.
Publicado: (2017)

Specific micro-RNA expression patterns distinguish the basal and luminal subtypes of muscle-invasive bladder cancer
por: Ochoa, Andrea E., et al.
Publicado: (2016)

Dynamics of telomeric repeat-containing RNA expression in early embryonic cleavage stages with regards to maternal age
por: Kordowitzki, Paweł, et al.
Publicado: (2020)

p73 expression is regulated by ribosomal protein RPL26 through mRNA translation and protein stability
por: Zhang, Min, et al.
Publicado: (2016)

MCL-1-independent mechanisms of synergy between dual PI3K/mTOR and BCL-2 inhibition in diffuse large B cell lymphoma
por: Lee, J. Scott, et al.
Publicado: (2015)

An interferon signature identified by RNA-sequencing of mammary tissues varies across the estrous cycle and is predictive of metastasis-free survival
por: Snijders, Antoine M., et al.
Publicado: (2014)

IL2RG, identified as overexpressed by RNA-seq profiling of pancreatic intraepithelial neoplasia, mediates pancreatic cancer growth
por: Ayars, Michael, et al.
Publicado: (2017)

First-in-Human Phase 1 Trial of Agarose Beads Containing Murine RENCA Cells in Advanced Solid Tumors
por: Smith, Barry H., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_sarlv04k3ju2vsn7lbngoomclf