Structure based discovery of clomifene as a potent inhibitor of cancer-associated mutant IDH1

Isocitrate dehydrogenase (IDH) plays an indispensable role in the tricarboxylic acid cycle, and IDH mutations are present in nearly 75% of glioma and 20% of acute myeloid leukemia. One IDH1R132H inhibitor (clomifene citrate) was found by virtual screening method, which can selectively suppress mutan...

Descripción completa

Detalles Bibliográficos
Autores principales: Zheng, Mengzhu, Sun, Weiguang, Gao, Suyu, Luan, Shanshan, Li, Dan, Chen, Renqi, Zhang, Qian, Chen, Lixia, Huang, Jiangeng, Li, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546478/
https://www.ncbi.nlm.nih.gov/pubmed/28498812
http://dx.doi.org/10.18632/oncotarget.17464

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546478/
https://www.ncbi.nlm.nih.gov/pubmed/28498812
http://dx.doi.org/10.18632/oncotarget.17464

Ejemplares similares