Histone modifications affect differential regulation of TGFβ- induced NADPH oxidase 4 (NOX4) by wild-type and mutant p53

Previously, we showed wild-type (WT) and mutant (mut) p53 differentially regulate reactive oxygen species (ROS) generation by NADPH oxidase-4 (NOX4): p53-WT suppresses TGFβ-induced NOX4, ROS and cell migration, whereas tumor-associated mut-p53 proteins enhance NOX4 expression and cell migration. Her...

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Detalles Bibliográficos
Autores principales: Boudreau, Howard E., Ma, Wei Feng, Korzeniowska, Agnieszka, Park, Jonathan J., Bhagwat, Medha A., Leto, Thomas L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546487/
https://www.ncbi.nlm.nih.gov/pubmed/28574838
http://dx.doi.org/10.18632/oncotarget.17892

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546487/
https://www.ncbi.nlm.nih.gov/pubmed/28574838
http://dx.doi.org/10.18632/oncotarget.17892

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