Genome-wide analysis of ivermectin response by Onchocerca volvulus reveals that genetic drift and soft selective sweeps contribute to loss of drug sensitivity

BACKGROUND: Treatment of onchocerciasis using mass ivermectin administration has reduced morbidity and transmission throughout Africa and Central/South America. Mass drug administration is likely to exert selection pressure on parasites, and phenotypic and genetic changes in several Onchocerca volvu...

Descripción completa

Detalles Bibliográficos
Autores principales: Doyle, Stephen R., Bourguinat, Catherine, Nana-Djeunga, Hugues C., Kengne-Ouafo, Jonas A., Pion, Sébastien D. S., Bopda, Jean, Kamgno, Joseph, Wanji, Samuel, Che, Hua, Kuesel, Annette C., Walker, Martin, Basáñez, Maria-Gloria, Boakye, Daniel A., Osei-Atweneboana, Mike Y., Boussinesq, Michel, Prichard, Roger K., Grant, Warwick N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546710/
https://www.ncbi.nlm.nih.gov/pubmed/28746337
http://dx.doi.org/10.1371/journal.pntd.0005816

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546710/
https://www.ncbi.nlm.nih.gov/pubmed/28746337
http://dx.doi.org/10.1371/journal.pntd.0005816

Ejemplares similares